"If R&O’s is known for roast beef, Parkway for shrimp, and Liuzza’s for garlic oyster, it’s safe to say Domilise’s is known for all of the above equally. Around since 1918, Domilise’s started as a bar and transitioned into a spot for plate lunches for longshoremen and river front workers, and is now one of the most well-known po’ boy shops in the city. We vote for the shrimp here." - Eater Staff
"It’s impossible to say which shop has the best po’ boys, but this Uptown contender is always in the running. Domilise’s doesn’t look like much from the outside, a nondescript corner shop identified only with a hand-printed sign for decades. Inside, longtime employees sling giant versions of the iconic sandwiches to locals, politicians, visiting celebrities, and anyone with good taste. The po’ boys might be considered pricey (a large shrimp goes for about $16), but they’re generous and worth every penny, especially the melt in your mouth roast beef and crispy fried shrimp. Always say yes to the sandwich fully dressed, topped with shredded lettuce, tomatoes, pickles, and mayonnaise." - Beth D’Addono
"Domilise’s is the po’boy shop equivalent of your cooler, older friend’s house. You know, the one that’s full of joyful relics that remind you of the good ol’ days. The menu here is handwritten, the tables are all laminated, and awards and photos of customers and employees fill the walls. And when it comes to po’boys, the sandwiches inspire that same fuzzy feeling. The top option is the weiner po’boy that comes topped with all the usual dressings, plus a sauce that tastes like chili but has the consistency of ketchup. But really, the fried shrimp, catfish, and roast beef are all great choices, too. Half the fun of coming here is watching your sandwich get made right by the door—odds are you’ll probably make a friend in line." - megan braden perry
"Domilise’s is the po’boy shop equivalent of your cooler, older friend’s house. You know, the one that’s full of joyful relics that remind you of the good ol’ days. The menu here is handwritten, the tables are all laminated, and awards and photos of customers and employees fill the walls. And when it comes to po’boys, the sandwiches inspire that same fuzzy feeling. The top option is the weiner po’boy that comes topped with all the usual dressings, plus a sauce that tastes like chili but has the consistency of ketchup. But really, the fried shrimp, catfish, and roast beef are all great choices, too. Half the fun of coming here is watching your sandwich get made right by the door—odds are you’ll probably make a friend in line. photo credit: Cory Fontenot photo credit: Cory Fontenot photo credit: Cory Fontenot photo credit: Cory Fontenot Pause Unmute" - Megan Braden-Perry
"The longtime po’ boy destination in the “Sliver by the River” has something of a cult following. Easy to miss, a hand-painted sign signals the entrance to a no-frills time warp of Formica and wood paneling. Like Parkway, Domilise’s has a long history tied to the city’s working class, and the family business marked its 100th anniversary in 2018. Both fried seafood and roast beef debris are customer favorites here." - Eater Staff