Domilise's, a century-old gem in Uptown, serves up massive, mouthwatering po' boys with a side of local charm and cold beer, perfect for any foodie adventure.
"Domilise’s is the po’boy shop equivalent of your cooler, older friend’s house. You know, the one that’s full of joyful relics that remind you of the good ol’ days. The menu here is handwritten, the tables are all laminated, and awards and photos of customers and employees fill the walls. And when it comes to po’boys, the sandwiches inspire that same fuzzy feeling. The top option is the weiner po’boy that comes topped with all the usual dressings, plus a sauce that tastes like chili but has the consistency of ketchup. But really, the fried shrimp, catfish, and roast beef are all great choices, too. Half the fun of coming here is watching your sandwich get made right by the door—odds are you’ll probably make a friend in line." - megan braden perry
"Domilise’s is the po’boy shop equivalent of your cooler, older friend’s house. You know, the one that’s full of joyful relics that remind you of the good ol’ days. The menu here is handwritten, the tables are all laminated, and awards and photos of customers and employees fill the walls. And when it comes to po’boys, the sandwiches inspire that same fuzzy feeling. The top option is the weiner po’boy that comes topped with all the usual dressings, plus a sauce that tastes like chili but has the consistency of ketchup. But really, the fried shrimp, catfish, and roast beef are all great choices, too. Half the fun of coming here is watching your sandwich get made right by the door—odds are you’ll probably make a friend in line. photo credit: Cory Fontenot photo credit: Cory Fontenot photo credit: Cory Fontenot photo credit: Cory Fontenot" - Megan Braden-Perry
"The longtime po’ boy destination in the “Sliver by the River” has something of a cult following. Easy to miss, a hand-painted sign signals the entrance to a no-frills time warp of Formica and wood paneling. Like Parkway, Domilise’s has a long history tied to the city’s working class, and the family business marked its 100th anniversary in 2018. Both fried seafood and roast beef debris are customer favorites here." - Eater Staff
"It’s impossible to say any shop has the best po’ boys, but these make a strong claim to that title. Domilise’s doesn’t look like much from the outside on an Uptown corner; adorned only with a hand-printed sign, it’s been that way for decades. Inside, longtime employees sling giant versions of the iconic sandwiches to locals, politicians, visiting celebrities, and anyone with good taste. The po’ boys might be considered pricey (a large shrimp one goes for about $16), but they’re generous and worth every penny, especially the melty roast beef and crispy fried shrimp, fully dressed — meaning topped with shredded lettuce, tomatoes, pickles, and mayonnaise." - Clair Lorell
"Recommended for po'boys, with Domilise's offering an off-menu special of fried shrimp and roast beef." - Regan Stephens
