Since 1924, this charming little spot serves legendary po' boys and cold beer, all wrapped in a nostalgic, no-frills vibe that screams New Orleans.
"The longtime po’ boy destination in the “Sliver by the River” has something of a cult following. Easy to miss, a hand-painted sign signals the entrance to a no-frills time warp of Formica and wood paneling. Like Parkway, Domilise’s has a long history tied to the city’s working class, and the family business marked its 100th anniversary in 2018. Both fried seafood and roast beef debris are customer favorites here." - Eater Staff
"It’s impossible to say any shop has the best po’ boys, but these make a strong claim to that title. Domilise’s doesn’t look like much from the outside on an Uptown corner; adorned only with a hand-printed sign, it’s been that way for decades. Inside, longtime employees sling giant versions of the iconic sandwiches to locals, politicians, visiting celebrities, and anyone with good taste. The po’ boys might be considered pricey (a large shrimp one goes for about $16), but they’re generous and worth every penny, especially the melty roast beef and crispy fried shrimp, fully dressed — meaning topped with shredded lettuce, tomatoes, pickles, and mayonnaise." - Clair Lorell
"Recommended for po'boys, with Domilise's offering an off-menu special of fried shrimp and roast beef." - Regan Stephens
"If R&O’s is known for roast beef, Parkway for shrimp, and Liuzza’s for garlic oyster, it’s safe to say Domilise’s is known for all of the above equally. Around since 1918, Domilise’s started as a bar and transitioned into a spot for plate lunches for longshoremen and river front workers, and is now one of the most well-known po’ boy shops in the city. We vote for the shrimp here." - Clair Lorell, Eater Staff
"Domilise's is a po' boy institution dating back to 1918, and what many consider the classic po' boy operation in New Orleans. It's an incredibly delicious hole-in-the-wall experience, where you can't go wrong with a fried shrimp or oyster, dressed." - Eater Staff