"All That Glitters Active from the 13th to 15th centuries and considered an influence on the pre-Renaissance movement, the Sienese School of painting is identifiable by its themes—always religious, and usually with a focus on Biblical miracles—and its signature style, a dreamy mix of Roman, Gothic, and Byzantine influences that often feature dazzling gold backgrounds. Opened in 1932, this museum boasts one of the world’s largest collections of Sienese School works, as well as a number of Renaissance and late-medieval pieces from Italian artists. Wander through the impressive building—a combination of two 14th- and 15th-century noblemen’s palazzi—to find works like Duccio’s Madonna and Child , Michelino da Besozzo’s Mystical Marriage of Saint Catherine (celebrating the “calling” of Siena’s native daughter), and Bartolo di Fredi’s expansive Adoration of the Magi . Paired with a visit to Florence’s Uffizi, coming here offers insight into the differences—and longtime rivalry—between the two cities."

"Inspiring Food Close to the Campo One of the best places to eat in Siena lies a few minutes’ walk from historic Piazza del Campo and inhabits an atmospheric room lined with old glass and wood cabinets full of books and wine bottles. It may be informal, but the gourmet food is top notch: Malfatti (spinach-and-ricotta gnocchi) dressed with a fresh tomato sauce, veal cheek served with stuffed porcini mushrooms and blackberries, and the brilliant wine list are all inspiring."

"Frescoes and Medical History at Santa Maria della Scala Founded in the 9th century, Santa Maria della Scala was one of Europe’s first hospitals. It was also one of the first hospitals anywhere to disinfect its equipment and only stopped taking in patients in the 1980s. (The writer Italo Calvino died here in 1961.) The early history of the hospital is illustrated in the 15th-century frescoes decorating the walls of the Pilgrim’s Hall, and there is a fascinating archaeological museum housed in the labyrinthine basement rooms."

"The Heart of Siena Considered one of Europe’s greatest medieval squares, the Piazza del Campo—or, simply, Il Campo—has been at the heart of life in Siena since it began as a marketplace and meeting spot for the area’s villages; the nine-lined, fishbone-patterned red-brick pavement was laid in the 14th century, giving the shell-shaped square more formal boundaries. Today, Il Campo hosts all the city’s major festivals and events, like the biannual Palio horse race, and is home to a variety of notable sites, including the 14th-century Torre del Mangia brick-faced tower, and the Palazzo Pubblico and Civic Museum, with its rich collection of Sienese School masterpieces. The cafés and restaurants around the square provide welcome shade and sustenance—and great people-watching opportunities—after a day spent exploring the city."